Interferon-a/ß receptor a chain precursor (IFNAR1) is part of a heterodimeric receptor and contains an intracellular motif with a unique peptide sequence. The gene encoding it is localized on chromosome 21.
Synonyms: Anti-IFN-alpha-REC; Anti-Interferon-alpha/beta receptor alpha chain precursor
Storage: -20C
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Biochem Physiol Actions: Interferon-a/ß receptor a chain precursor (IFNAR1) acts as a receptor for the pro-inflammatory cytokine interferon a (IFN-a) and is involved in immune processes during malaria infection. When IFN-a binds to IFNAR1, Janus kinases (JAKs) are activated. They then phosphorylate signal transducer and activator of transcription 1 (STAT1) and STAT2. This complex then enters the nucleus and activates antiviral gene transcription. Single-nucleotide polymorphisms in IFNAR1 have shown to be risk factors for malaria. IFNAR1 is down regulated in Hepatitis C Virus (HCV)-linked chronic liver diseases.
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