Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
Synonyms: Ido1, Indoleamine 2,3-dioxygenase 1, IDO-1, Indoleamine-pyrrole 2,3-dioxygenase
Application: Western Blotting Analysis: A representative lot detected Ido1 in splenic dendric cells from WT or KO mouse tissue lysate (Oberdan Leo, Universite Libre de Bruxelles).Flow Cytometry Analysis: A representative lot detected Ido1 in splenic dendric cells from mouse (Oberdan Leo, Universite Libre de Bruxelles).
Other Notes: Concentration: Please refer to lot specific datasheet.