Synonyms: Anti-Alpha-crystallin C chain; Anti-E2-induced gene 1 protein; Anti-Heat shock protein beta-8; Anti-HspB8; Anti-Protein kinase H11; Anti-Small stress protein-like protein HSP22
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Heat shock protein ß-8 is a protein encoded by the HSPB8 gene in humans. It is a small HSP expressed ubiquitously in various tissues that serves as a positive regulator in TGF-a-induced migration of ovarian cancer cells. This gene is associated with aggressiveness and prognosis of tumor cells, thereby protecting tumor cell from apoptosis in many malignancies. Mutation in this gene (i.e. missense mutation) may lead to distal hereditary motor neuropathy (dHMN) and axonal Charcot-Marie-Tooth disease (CMT2L).
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