The gene HSD17B14 (17-ß-hydroxysteroid dehydrogenase 14) is mapped to human chromosome 19q13.33. It belongs to 17ß hydroxysteroid dehydrogenases (17ßHSDs) family of proteins. HSD17B14 is strongly expressed in the brain, liver and placenta. The protein localizes in the cytoplasm.
Synonyms: Anti-17-beta-HSD 1; Anti-17-beta-hydroxysteroid dehydrogenase type 1; Anti-20 alpha-hydroxysteroid dehydrogenase; Anti-20-alpha-HSD; Anti-E2DH; Anti-Estradiol 17-beta-dehydrogenase 1; Anti-Placental 17-beta-hydroxysteroid dehydrogenase
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: 17ß hydroxysteroid dehydrogenases (17ßHSDs) are mainly involved in oxidation/reduction at position C17 of sex steroids. HSD17B14 oxidizes estradiol and testosterone into less bioactive steroid metabolites. Humans with high levels of HSD17B14 have lower local recurrences of estrogen positive breast cancer when treated with tamoxifen.
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