Hepatocyte nuclear factor -4 ? (HNF4G) belongs to the nuclear receptor superfamily and is an orphan receptor with significant homology to HNF4a. The gene for HNF-4? is located on chromosome 8q. HNF-4? is expressed in small intestine, testis, pancreas and kidney. Studies reveal that the ligand binding domain of HNF-4? has constitutively bound fatty acids, which are endogenous in origin. HNF-4? protein is composed of 774 amino acids.
Synonyms: Anti-HNF-4-gamma; Anti-Hepatocyte nuclear factor 4-gamma; Anti-Nuclear receptor subfamily 2 group A member 2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Hepatocyte nuclear factor -4 ? (HNF4G) protein forms heterodimers with HNF-4a, and together they are involved in the regulation of metabolism. They also induce the expression of various genes, including cell death-inducing DEF45-like effector b (CIDEB), which regulates lipid metabolism in the liver. In humans, the expression of dihydrodiol dehydrogenase (DD) is regulated by HNF-4?. DD is responsible for the reduction of various ketone-containing drugs and the oxidation of trans-dihydrodiols of polycyclic aromatic hydrocarbons.
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