HNF4A (hepatocyte nuclear factor 4, a) is a transcription factor, expressed in liver, kidney, pancreatic islets and intestine. It is a member of the nuclear receptor family of ligand-activated transcription factors.
Synonyms: Anti-HNF-4-alpha antibody produced in rabbit; Anti-Hepatocyte nuclear factor 4-alpha antibody produced in rabbit; Anti-Transcription factor 14 antibody produced in rabbit; Anti-Transcription factor HNF-4 antibody produced in rabbit
Storage: -20C
Application: Anti-HNF4A antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: HNF4A (hepatocyte nuclear factor 4, a) is involved in controlling gene expression of liver, pancreas, kidney, intestine, and other tissues. It activates hepatocyte nuclear factor 1a (HNF1A). The activated HNF1A further triggers liver specific gene expression associated with glucose, cholesterol and fatty acid metabolism. It acts as a biomarker in gastric and breast carcinomas. It has reported that, HNF4A controls glucose-stimulated insulin secretion. Hence, mutation in the HNF4A gene causes hyperinsulinaemic hypoglycaemia and maturity-onset diabetes in early life.
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