HNF1B (hepatocyte nuclear factor 1 ß), a homeodomain, is an atypical POU (Pit-1, Oct-1, andUnc-86) transcription factor which is associated with the early vertebrate development and embryonic survival. It is expressed in the pancreas, kidney, lung, ovary, testis, and throughout the gastrointestinal tract.
Synonyms: HNF1B Antibody - Anti-HNF1B antibody produced in rabbit; Hnf1B Antibody; Anti-HNF-1beta; Anti-LFB3; Anti-MODY5; Anti-TCF2; Anti-TCF2; Anti-VHNF1
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunocytochemistry (1 paper)
Biochem Physiol Actions: The expression of HNF1B (hepatocyte nuclear factor 1 ß) is upregulated in papillary renal cell tumours (RCTs) as well as in some conventional RCCs, renal oncocytomas, chromophobe RCCs and normal kidneys. On the other hand, its expression is suppressed in Wilms'tumours. It is a nuclear protein required for liver-specific expression. It can binds to the promoters and enhancers of a variety of genes expressed in liver along with the proximal element (PE) of the albumin gene.
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