The gene encoding HIF1A (hypoxia inducible factor 1 subunit a) is localized on human chromosome 14q23.2. It is part of the HIF-1 heterodimer complex and is modulated by oxygen.
Synonyms: Anti-ARNT-interacting protein antibody produced in rabbit; Anti-Basic-helix-loop-helix-PAS protein MOP1 antibody produced in rabbit; Anti-HIF-1 alpha antibody produced in rabbit; Anti-HIF1 alpha antibody produced in rabbit; Anti-Hypoxia-inducible factor 1 alpha antibody produced in rabbit; Anti-Member of PAS protein 1 antibody produced in rabbit
MDL Number: MFCD01633488
Storage: -20C
Application: Rabbit polyclonal anti-HIF1A antibody is used to tag hypoxia-inducible factor 1 a for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of hypoxia-inducible factor 1 a in the structure and function of hypoxia-inducible factor 1.
Biochem Physiol Actions: Hypoxia-inducible factor 1, alpha subunit (HIF1A) combines with aryl hydrocarbon receptor nuclear translocator (Arnt, HIF1B), the beta subunit to create the heterodimeric basic helix-loop-helix transcription factor hypoxia-inducible factor 1. Many hypoxia-regulated genes are mediated by the hypoxia-inducible factor 1 (HIF-1) complex. HIF-1 binds to the promoter of hypoxia-responsive genes and other transcription factors, such as p300, signal and transducer of transcription 3, and redox effector factor 1/apurinic/apyrimidinic endonuclease.
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