The gene HAPLN1 (hyaluronan and proteoglycan link protein 1) is mapped to human chromosome 5q14.3. It belongs to HAPLN gene family.
Synonyms: Anti-Cartilage link protein; Anti-Hyaluronan and proteoglycan link protein 1; Anti-LP; Anti-Proteoglycan link protein
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: HAPLN1 (hyaluronan and proteoglycan link protein 1) is a crucial component of the cartilage extracellular matrix. It is responsible for connecting proteoglycans to hyaluronic acid, and thereby regulates compression resistance and shock absorption in the joints. HAPLN1 is down-regulated in Kashin-Beck disease and primary osteoarthritis. Single nucleotide polymorphism in HAPLN1 is linked with spinal osteophyte formation and disc degeneration.
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