Glycogenin 2 (GYG2) is a key enzyme in the synthesis of glycogen. It is a self-glycosylating protein. This gene spans 46kb, has 11 exons and localizes to chromosome Xp22.3. GYG2 is expressed in liver, heart and pancreas. It has 3 isoforms- glycogenins-a, ß and ?. Glycogenin-2ß is the major isoform to be expressed in liver.
Synonyms: Anti-GN-2 antibody produced in rabbit; Anti-GN2 antibody produced in rabbit; Anti-Glycogenin-2 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Glycogenin-2 (GYG2) plays a major role in the synthesis of glycogen in liver. It initiates glycogen synthesis by forming the first glucose-O-tyrosine linkage in the presence of UDP-glucose. It forms homodimers as well as heterodimers with glycogenin-1. Glycogenin-1 facilitates self-glucosylation of glycogenin-2, with the vice-versa not being true. GYG2 can regulate glycogen synthesis, and the levels of GYG2 are correlated to the amount of glycogen present in liver. Studies suggest that there might be an association between mutations in this gene and Leigh syndrome (LS), which is an early-onset neurodegenerative disorder.
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