Synonyms: Anti-Biogenic amine receptor-like G-protein coupled receptor; Anti-Probable G-protein coupled receptor 61
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: GPR61 (G-protein coupled receptor 61) gene is a member of the G-protein coupled receptor 1 family. The gene encodes an orphan receptor that is predominantly expressed in the brain, implicating its role in several physiological functions in the central nervous system. GPR61 deficiency in mice causes obesity associated with hyperphagia, which suggests that it may be involved in the regulation of food-intake and body weight. It may serve as a therapeutic target during the treatment of obesity or eating disorders. The N-terminal domain of this protein that functions as a tethered intramolecular ligand is found to be essential for its constitutive activity. The function of this gene in humans is yet to be elucidated.
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