The gene GPR31 (G protein-coupled receptor 31) encodes a member of the GPCR family. The proteins belonging to this family are characterized by the presence of seven transmembrane domains. The encoded protein is around 319 amino acid long and belongs to the rhodopsin-like group A subfamily. The gene is mapped to human chromosome 6q27.
Synonyms: Anti-Probable G-protein coupled receptor 31
Storage: -20C
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Biochem Physiol Actions: The gene GPR31 (G protein-coupled receptor 31) encodes an orphan G protein-coupled receptor that binds to 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE), a human 12-lipoxygenase-derived product. It is localized to the plasma membrane and is also referred to as 12-HETER (12-(S)-HETE receptor). It also binds to 12-(S)-HETE hydroxyl fatty acids with high affinity. The binding partner, 12-(S)-HETE, functions in several processes including cytoskeleton remodeling, stimulation of cells to secrete proteinases and vascular endothelial growth factor resulting in an angiogenic response. The binding of 12-(S)-HETE to GPR31 activates MEK (MAPK/ERK kinase), ERK1/2 (extracelular signal regulated kinase), and NF?B (nuclear factor) signaling molecules. This ligand-receptor complex is also involved in the regulation of tumor cell invasion.
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