GPR17 (G protein-coupled receptor 17) is a Gi-coupled GPCR, that serve as an intrinsic timer of oligodendrocyte differentiation and myelination. In central nervous system, it is present in the oligodendrocyte lineage cells.
Synonyms: Anti-G protein-coupled receptor 17
Storage: -20C
Application: Anti-GPR17 has been used in immunohistochemistry.
Biochem Physiol Actions: GPR17 acts as a reliable marker to identify an intermediate phase of OPC (oligodendrocyte precursor cells) differentiation. It plays a valuable role in remyelination after brain tissue damage. It also plays a complicated role in the modulation of oligodendrocyte maturation. Hence it is considered as an important regulator of oligodendrogenesis.
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