Synonyms: Anti-Probable G-protein coupled receptor 158 precursor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: GPR158 (G protein-coupled receptor 158) gene encodes an orphan member of the G protein-coupled receptor family that contain seven transmembrane regions. It is involved in the control of the localization and activity of the RGS7 (R7 family of regulator of G protein signaling) complexes that function in synaptic transmission, light perception, and sensitivity to addictive drugs by regulating several GPCR pathways. It recruits the RGS complex to the plasma membrane and facilitates GPCR signaling.
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