The GFAP (glial fibrillary acidic protein) gene encodes an intermediate protein filament-III (50kDa). It is localized particularly to the astrocytes and non-myelinating Schwann cells of the central and peripheral nervous system, respectively.
Synonyms: GFAP Antibody Sigma - Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit; Gfap Antibody Sigma; Anti-GFAP
MDL Number: MFCD00145904
Storage: -20C
Application: Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit is suitable for:
•immunohistochemical staining at a working dilution of 1:400 using rat brain sections
•immunohistochemical staining of human brain tumor tissue specimens to identify the cells expressing AQP4 (Aquaporin-4)
•immunofluorescence using brain section from miceThe antibody is suitable for immunohistochemistry at a working dilution of 1:80 using alcohol- and formalin-fixed, paraffin-embedded sections of human or animal brain tissue. It is also suitable for indirect immunoblotting at a working dilution of 1:500 using human brain extract blot and microarray.
Biochem Physiol Actions: Glial fibrillary acidic protein may be used as a marker for distinguishing astrocytes from other glial cells during development of the central nervous system. GFAP is responsible for maintaining the structure of glial cells. It also offers mechanical strength and support to the surrounding neurons and blood brain barrier. Defects in this gene causes Alexander disease, indicated by Rosenthal fibers deposition. It is a rare disorder of astrocytes in the central nervous system. Increased GFAP expression indicates astrogliosis, a sign of neurodegeneration and neuroinflammation.
RIDADR: NONH for all modes of transport
WGK Germany: 2