Histone acetyltransferase KAT2A (EC 2.3.1.48; UniProt Q92830; also known as General control of amino acid synthesis protein 5-like 2, hGCN5, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97) is encoded by the KAT2A (also known as GCN5, GCN5L2, HGCN5) gene (Gene ID 2648) in human. Histone acetyltransferases (HATs) are transcription co-activators recruited by transcriptional activators to target gene promoters, where they enhance the transcription activity by acetylating lysine residues within the N-terminal regions of histones. KAT2A/KAT2B, MYST (MOZ, Ybf2 (Sas3), Sas2, and Tip60), TAFII250, CREBBP/EP300, and SRC represent the five HAT families. In addtion to functioning as transcription co-activators, KAT2A (GCN5) and KAT2B (PCAF) are also reported to repress IFN‐beta production and innate antiviral immunity by inhibiting the innate immune signaling kinase TBK1 in the cytoplasm in a HAT‐independent and non‐transcriptional manner.
Synonyms: Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, hGCN5, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97
Application: Western Blotting Analysis: 1.2 µg/mL from a representative lot detected Gcn5 immunoprecipited from HeLa nuclear extract.Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot immunoprecipitated KAT2A/GCN5-associated DNA fragments by ChIP using chromatin preparations from murine CH12 and human GM12878 lymphoblasts (Cheng, Y., et al. (2014). Nature. 515(7527):371-375).ChIP-seq Analysis: A representative lot was employed to generate Gcn5 genome-wide binding profiles by ChIP-seq analysis using chromatin preparations from murine CH12 and human GM12878 lymphoblasts (Cheng, Y., et al. (2014). Nature. 515(7527):371-375).
Other Notes: Concentration: Please refer to lot specific datasheet.