GCN1 (General control of amino-acid synthesis 1-like 1, yeast) is a large 297kDa protein of a ATP-binding cassette (ABC) superfamily. It possesses strong structural similarity with elongation factor 3 (EF3). It is localized in the cellular membrane and can interact with translating 80S ribosomes.
Synonyms: Anti-GCN1L; Anti-GCN1L1; Anti-KIAA0219
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: GCN1 (General control of amino-acid synthesis 1-like 1, yeast) is a translational regulators. It functions as a subunit of a protein complex required for the stimulation of GCN2 kinase activity under amino acid starved conditions.
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