Growth-arrest specific 8 (Gas8) is also termed as growth arrest specific 11 (GAS11). It spans around 25 kb and has 11 exons. GAS8 is expressed in various mammalian cells that has no motile cilia. This gene is located on human chromosome 16q24.3. In vertebrate cells, GAS8 is located to the axoneme of motile cilia and also to the base of primary cilia.
Synonyms: Anti-GAS11; Anti-growth arrest-specific 8
Storage: -20C
Application: Anti-GAS8 antibody has been used in western blotting.
Biochem Physiol Actions: In primary cilium, growth-arrest specific 8 (Gas8) controls hedgehog signaling and in motile cilia, it contributes to the cilia movement. Mutations in GAS8 are linked with primary ciliary dyskinesia (PCD) in humans.
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