Gapvd1 (GTPase activating protein and VPS9 domains 1) is an endosome-associated protein and an activator of Rab. It is also known as RAP6 (Rab5-activating protein 6), Gapex-5 (GTPase activating protein) or RME-6 (receptor-mediated endocytosis protein 6).
Synonyms: Anti-DKFZP434C212; Anti-GTPase activating protein and VPS9 domains 1; Anti-GUSBP2; Anti-GUSBP4; Anti-KIAA1521; Anti-SMA3-L; Anti-SMAC3L; Anti-SMAC3L2; Anti-bA239L20.1; Anti-bA239L20.5; Anti-bGLU-Lp
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Gapvd1 (GTPase activating protein and VPS9 domains 1) interacts with Vav2 (vav guanine nucleotide exchange factor 2) and thereby modulates EGFR (epidermal growth factor receptor) stability. It also modulates vesicular trafficking processes like endocytosis of activated transmembrane proteins and exocytosis of GLUT4 (glucose transporter/solute carrier family 2) vesicles. Gapvd1 participates in phagosome maturation and also have a role in eye development or embryogenesis.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC