Synonyms: Anti-Axonal membrane protein GAP-43; Anti-Growth-associated protein 43; Anti-Neural phosphoprotein B-50; Anti-Neuromodulin; Anti-PP46
MDL Number: MFCD00164594
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Growth Associated Protein 43 (also known as GAP43) is a membrane-associated phosphoprotein encoded by the GAP43 gene in humans. It is expressed in neuronal growth cones and Schwann cell precursors during neural development, axonal regeneration and also in malignant peripheral nerve sheath tumors. It acts as a highly sensitive and useful diagnostic marker for peripheral nerve sheath tumors. It is also essential for reorganization of synaptic connections and regenerating nerve fibers.
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