Synonyms: Anti-Galactowaldenase antibody produced in rabbit; Anti-UDP-galactose 4-epimerase antibody produced in rabbit; Anti-UDP-glucose 4-epimerase antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: GALE (UDP-galactose-4-epimerase) gene encodes an enzyme that catalyzes the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine, which are used as precursors for the synthesis of glycoproteins and glycolipids. It is essential for the interconversion of UDP-galactose and UDP-glucose, an important step in the Leloir pathway of galactose metabolism. Mutations in this gene cause epimerase-deficiency galactosemia that is characterized by extensive allelic heterogeneity. It requires NAD+ as the cofactor.
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