GABPB1 (GA binding protein transcription factor, ß subunit 1) is a 414-amino acids containing protein belonging to the Ets (E26 transformation-specific or E-twenty-six) family of transcription factor. It contains N-terminal ankyrin repeat region.
Synonyms: Anti-GA-binding protein subunit beta-1; Anti-GABP subunit beta-1; Anti-GABP subunit beta-2; Anti-GABPB-1; Anti-GABPB-2; Anti-GABPB2 antibody produced in rabbit; Anti-Nuclear respiratory factor 2; Anti-Transcription factor E4TF1-47; Anti-Transcription factor E4TF1-53
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: GABPB1 (GA binding protein transcription factor, ß subunit 1) plays a key role in transcriptional regulation. It has ability to form homodimer as well as heterodimer with GABPß1L. It has been predicted that GABPB1 exerts a distinct role in regulating lymphocyte development including B cell expansion and humoral responses. GABPB1 controls autophagy through the activation of BECN1-PIK3C3 (Beclin 1-phosphatidylinositol 3-kinase) complex.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC