Synonyms: Anti-gamma-Aminobutyric Acid Type A Receptor (alpha6 subunit)
MDL No.: MFCD07370321
Storage: -20C
UNSPSC Code: 12352203
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General description: γ -aminobutyric acid (GABA) receptor is the multifunctional, pentameric membrane proteins that operate GABA-gated chloride channels. It acts as major inhibitory neurotransmitter in the adult mammalian brain. It is the members of the neurotransmitter ligand-gated ion channels which plays various functions in the central nervous system, the peripheral nervous system, and in some nonneuronal tissues. At least four types of subunits (α, β, γ and δ) of GABA have been identified. Generally it contains one type of α and β subunit, and a single γ polypeptide in a ratio of 2:2:1.
Application: Anti-GABAA Receptor (alpha6 subunit), cytosolic loop antibody is suitable for western blot at a dilution of 1:1,000 using rat brain membrane fraction.
Biochem/physiol Actions: GABA is synthesized primarily from glutamate by glutamate decarboxylase (GAD). It is triggered by binding to its ligand-gated chloride channels, GABA(A) and GABA(C) as well as metabotropic receptor GABA(B). Along with neural development, it is also involved in a wide variety of physiological functions in tissues and organs outside the brain.
Immunogen: fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABAA receptor (alpha6 subunit)
Physical form: Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 mug/ml BSA and 50% glycerol.
Target description: Detects 56-57 kDa GABAA receptor alpha6 subunit in rat brain membrane fractions.