Forkhead box C1 (FOXC1) is encoded by the gene mapped to human chromosome 6p25.3. The gene is widely expressed in mesenchyme and codes for a member of the FOX family, which is characterized by a distinct DNA-binding forkhead domain.
Synonyms: Anti-ARA; Anti-FKHL7; Anti-FREAC3; Anti-Forkhead box C1; Anti-IGDA; Anti-IHG1; Anti-IRID1
Storage: -20C
Application: Anti-FOXC1 antibody produced in rabbit has been used in immunoprecipitation assay.
Biochem Physiol Actions: Forkhead box C1 (FOXC1) is involved in various developmental processes such as somatic, cardiovascular, kidney, eye, skull and cortical development. Mutation in the gene leads to Dandy-Walker malformation (DWM), Axenfeld-Rieger syndrome (ARS), congenital glaucoma and cerebral small-vessel disease (CSVD). Increased expression of FOXC1 improves invasion capacity of basal-like breast cancer (BLBC) in vitro and stimulates cancer development and metastasis in vivo.
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