FMNL (formin like) encodes a formin homology protein. It belongs to the formin family with three other members: FMNL1, FMNL2 and FMNL3.
Synonyms: Anti-Formin-like 3 isoform 2 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: FMNL3 (formin like 3) is involved in the regulation of Rho-related signaling pathway by controlling the polarity, invasion, migration or metastasis. FMNL3 plays a major role in morphology regulation, migration and cytoskeletal organization. It can regulate endothelial cells (ECs) elongation during angiogenesis. During angiogenesis, activated FMNL3 stimulates the alignment of microtubules for remodeling of the EC cytoskeleton. FMNL3 also controls the protrusion of actin-rich filopodia structures that helps in enhanced migration and invasion.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC