Synonyms: Anti-25 kDa FKBP antibody produced in rabbit; Anti-FK506-binding protein 3 antibody produced in rabbit; Anti-FKBP-25 antibody produced in rabbit; Anti-PPIase antibody produced in rabbit; Anti-Peptidyl-prolyl cis-trans isomerase antibody produced in rabbit; Anti-Rapamycin-selective 25 kDa immunophilin antibody produced in rabbit; Anti-Rotamase antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: FK506-binding protein 3 is a protein encoded by the FKBP3 gene in humans and belongs to FK506-binding proteins. The protein is found both in the cytoplasm compartment and in the nuclear proteome. It is a nuclear protein associated with chromatin modifiers and transcription factors. It interacts with numerous ribosomal proteins, ribosomal processing factors and a small selection of chromatin modifiers. The protein interacts with the immature large ribosomal subunit in nuclear extract (but does not associate with mature ribosomes). It is likely to recruite preribosomes to chaperone one of the protein components of the ribosome large subunit. The protein may have role in ribosome biogenesis. It is associated to diverse components that are part of several different intracellular large-molecular mass entities. FKBP3 is a high-affinity rapamycin-binding immunophilin having nuclear translocation signals present in its PPIase domain.
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