Synonyms: Anti-Acidic fibroblast growth factor intracellular-binding protein; Anti-FGF-1 intracellular-binding protein; Anti-aFGF intracellular-binding protein
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: FIBP (Fibroblast growth factor (acidic) intracellular binding protein is a hydrophilic, secreted protein with the binding capacity of fibroblast growth factors (FGFs) 1 and 2. It is localized mainly in the nucleus and involved in the signal transduction, cell proliferation, and angiogenesis. It acts as a molecular chaperone in transfer of locally stored FGF to its tyrosine kinase receptor. Post-translocation, it stimulates the tyrosine phosphorylation of the receptors followed by enhanced proto-oncogenes and mesoderm formation. It also controls the activities of FGF-1 and FGF-2.
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