FBXL4 (F-box and leucine-rich repeat 4 protein) belongs to the F-box family of proteins. It is a mitochondrial protein, essential for OXPHOS (oxidative phosphorylation) proficiency. It consists of a leucine-rich repeat domain, that is involved in protein-protein interactions.
Synonyms: Anti-60B8AG; Anti-CAGA; Anti-CFAG; Anti-CGLA; Anti-F-box and leucine-rich repeat protein 4; Anti-FBL4; Anti-FBL5; Anti-MRP8; Anti-P8
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collecation of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: FBXL4 (F-box and leucine-rich repeat 4 protein) participates in phosphorylation-dependent ubiquitination and/or G protein receptor coupling. It also plays a role in controlling bioenergetic homeostasis and mitochondrial DNA maintenance. Mutations in FBXL4 can cause early-onset mitochondrial encephalomyopathy.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC