Synonyms: Anti-Cadherin-related tumor suppressor homolog precursor; Anti-FAT; Anti-Protein fat homolog
MDL Number: MFCD00164626
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem Physiol Actions: FAT1 (FAT atypical cadherin 1), transmembrane protein belonging to the cadherin super family, encodes a large transmembrane protein with 34 tandem cadherin repeats, five EGF (epidermal growth factor)-like repeats, and a laminin A-G domain. It exhibits tumor suppressor activity. It is ubiquitously expressed in epithelial tissues. Specifically, FAT1 is localized to the cell membrane, often concentrated at filopodia, lamellipodia, and sites of cell-cell contact. In mammals, four isoforms have been found: FAT1, FAT2, FAT3 and FAT4. FAT1 helps to regulate cell-cell association and actin dynamics.
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