Phenylalanyl-tRNA synthetase, a multidomain, heterodimeric protein, belongs to the tRNA synthetase family with two subunits: the catalytic a-subunit and ß-subunit. It has quaternary structure (a2ß2 proteins).
Synonyms: Anti-CML33; Anti-PheRS; Anti-Phenylalanine--tRNA ligase alpha chain; Anti-Phenylalanyl-tRNA synthetase alpha chain
Storage: -20C
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Biochem Physiol Actions: FARSA (phenylalanyl-tRNA synthetase a subunit) is involved with the synthesis of Phe-tRNA(Phe) during protein synthesis. The a-subunit forms the catalytic core while ß-subunit helps in tRNA anticodon binding and editing of the misaminoacylated species Tyr-tRNA(Phe). It has been reported that in human, a-subunit is overexpressed in the tumorigenic cells of the acute-phase chronic myeloid leukemia cell line (CML).
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