ETS translocation variant 1 (ETV1) is transcriptional activator and is expressed in two isoforms. It has a winged helix-turn-helix ETS DNA binding motif. ETV1 is mapped to human chromosome 7p21.2.
Synonyms: ER81
Storage: -20C
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Biochem Physiol Actions: ETS translocation variant 1 (ETV1) plays a key role in signalling and development. Phosphorylation of ETV1 bymitogen- and stress-activated protein kinase 1 (MSK1) activates transcriptional regulation. ETV1 promotes tumor progression by triggering ETS transcription factors and is highly expressed gastrointestinal stromal tumours.
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