Anti-EpCAM antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma Ber-EP4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human breast carcinoma cell line MCF-7. EpCAM (Epithelial cell adhesion molecule) is a highly conserved type I transmembrane glycoprotein. EpCAM is present on most epithelia tissues of the adult body and in undifferentiated rather than differentiated embryonic stem cells.
Synonyms: Anti-CD326 antigen; Anti-EGP; Anti-Epithelial cell surface antigen; Anti-Epithelial glycoprotein; Anti-KS 1/4 antigen; Anti-KSA; Anti-Major gastrointestinal tumor-associated protein GA733-2; Anti-Tumor-associated calcium signal transducer 1
Storage: -20C
Application: Anti-EpCAM antibody has been used in:
•immunofluorescence
•immunohistochemistry
•immunoprecipitation
Biochem Physiol Actions: EpCAM (Epithelial cell adhesion molecule) regulates cell-cell contact adhesion strength and tissue plasticity and epithelial cell proliferation and differentiation. Mutations in EpCAM are associated with several intestinal abnormalities such as Lynch syndrome, and congenital tufting enteropathy (CTE). Anti-EpCAM has been proved valuable for the distinction of undifferentiated primary or metastatic tumors from non-epithelial tumors, bile duct cells from hepatocytes in certain liver diseases, and between epithelial and normal reactive or neoplastic mesothelial cells from carcinoma cells.