Synonyms: Anti-Egl nine homolog 3 (C. elegans); Anti-FLJ21620; Anti-HIFPH3; Anti-MGC125998; Anti-MGC125999; Anti-PHD3
Storage: -20C
Biochem Physiol Actions: EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.