The gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol.
Synonyms: Anti-MST105; Anti-MSTP105; Anti-ZFYVE2; Monoclonal Anti-Early endosomal antigen 1
Storage: -20C
Application: Monoclonal Anti-EEA1 antibody produced in mouse is suitable for the following applications:
•Immunoprecipitation
•Indirect immunofluorescence
•Western blotting at a concentration of 1-2mug/mL using whole extract of rat NRK cells
Biochem Physiol Actions: Early Endosome Antigen 1 (EEA1) controls vesicle fusion during endocytosis. In neurons, it is involved in recycling of synaptic vesicles and neurotransmitter receptors. Patients with neurological deficits develop EEA1 autoantibodies. Mutation in EEA1 gene leads to susceptibility to diabetes in the Japanese population. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is essential for the localization and function of EEA1.