The gene EBP (emopamil binding protein), also referred to as CDPX2, is mapped to human chromosome Xp11.23-p11.22. The encoded protein is sublocalized in the ER (endoplasmic reticulum) and is expressed abundantly in the liver. It is also expressed in several other tissues.
Synonyms: Anti-Delta8,Delta7 sterol isomerase antibody produced in rabbit; Anti-3-beta-Hydroxysteroid-Delta8,Delta7-isomerase antibody produced in rabbit; Anti-Cholestenol Delta-isomerase antibody produced in rabbit; Anti-D8-D7 sterol isomerase antibody produced in rabbit; Anti-Emopamil-binding protein antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: EBP (emopamil binding protein) gene encodes an integral membrane protein of the endoplasmic reticulum. It serves as a binding protein for the phenylalkylamine Ca2+ antagonist emopamil. It is a high affinity receptor for antiischemic drugs and a potential target for antiischemic drug action. It contains sigma binding sites. The protein catalyzes the conversion of ?8-sterols to their corresponding ?7-isomers. Mutations in this gene cause Conradi-Hünermann syndrome characterized by aberrant punctate calcification in cartilage, or chondrodysplasia punctata (CDP).
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