Synonyms: Anti-Cytoplasmic dynein heavy chain 1 antibody produced in rabbit; Anti-DHC1 antibody produced in rabbit; Anti-DYHC antibody produced in rabbit; Anti-Dynein heavy chain 1, cytoplasmic 1 antibody produced in rabbit; Anti-Dynein heavy chain, cytosolic antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Cytoplasmic dynein 1 heavy chain 1 is a protein encoded by the DYNC1H1 gene in humans. It encodes the heavy chain of cytoplasmic dynein 1, a motor protein complex implicated in retrograde axonal transport, neuronal migration and other intracellular motility functions. Mutation in this gene may lead to autosomal-dominant Charcot-Marie-Tooth type 2, distal spinal muscular atrophy (SMA) mostly affecting the legs (SMA-LED) and intellectual disability.
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