DSG2 (Desmoglein 2) is a transmembrane glycoprotein belonging to the family of Ca(2+) dependent cell adhesion molecules, the cadherins. It is a largest protein of the cadherin family with a molecular weight of 116,760. It is expressed in all human and bovine desmosome-producing tissues, tumors, and epithelial-non- epithelial cell lines. It consists of a C-terminal unique region (Dsg unique region, DUR).
Synonyms: Anti-Desmoglein-2 precursor antibody produced in rabbit; Anti-HDGC antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: DSG2 (Desmoglein 2) is a junction-specific, cell surface cadherin involved in the formation of intercellular junctions called desmosomes. The DUR domain inhibits internalization via tail-tail interactions to stabilize the DSG2 molecule at the cell surface. It is associated with the intercellular adhesion and cell signaling mechanism. It also acts as a general biomarker in tumor diagnosis.
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