Synonyms: Anti-CG10523-PB; Anti-Cg10523-pc; Anti-Isoform B; Anti-Isoform c; Anti-PARKIN
Storage: -20C
UNSPSC Code: 12352203
General description: Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.
General description: Parkin gene is located on Drosophila melanogaster chromosome 78C2. This gene codes for the enzyme E3 ubiquitin ligase, which localizes in the cytosol.
Application: Anti-Drosophila Parkin (C-term) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions: Mutation in the parkin gene leads to Parkinson′s disease. The encoded protein is involved in quality control mechanism for the disposal of abnormal mitochondria, thereby maintaining lifespan and controlling locomotion. Parkin along with PTEN-induced putative kinase 1 (PINK1) targets mitochondria for its degradation through autophagy.
Immunogen: PARKIN (NP_730600, )This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Drosophila Parkin.
Physical form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: nwg