Synonyms: Anti-DRG 2 antibody produced in rabbit; Anti-Developmentally-regulated GTP-binding protein 2 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: DRG2 (developmentally regulated GTP binding protein 2) gene belongs to the developmentally regulated GTP-binding protein (DRG) subfamily. The encoded protein is a critical regulator of cell growth and differentiation. Abnormal expression of this gene affects cell transformation. Overexpression of DRG2 affects genes that are involved in the regulation of cell-cycle arrest and apoptosis. Increased expression of this protein leads to accumulation of cells in G2/M phase of the cell cycle. DRG family regulatory protein (DFRP) 1 regulates the expression of DRG2 through specific binding. The gene is localized to human chromosome 17p11.2, a region associated with Smith-Magenis syndrome.
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