Divalent metal ion transporter 1 (DMT1) is a proton-coupled Fe2+ transporter that is essential for iron uptake in enterocytes and for transferrin-associated endosomal iron transport in many other cell types. DMT1 dysfunction is associated with several diseases such as iron overload disorders and neurodegenerative diseases. DMT1 can transport manganese, cobalt, cadmium, nickel, and vanadium. DMT1 is also involved in iron transport from acidified endosomes into the cytoplasm in erythroid precursor cells as well as liver internal metabolism of iron. Interestingly too, in mammalian cells, mitochondria receive most incoming iron, and the outer mitochondrial membrane appears to be a major location for DMT1, which appears to be the major importer of iron into the mitochondria.
Synonyms: NRAM1, NRAMP 2, NRAMP-2, Divalent metal transporter 1, Divalent cation transporter 1, DMT-1
Application: Western Blot Analysis: 2 µg/ml of this antibody detected DMT1 in 50 µg of mouse liver, spleen and duodenum tissue lysate (Schumann, K.,et al. (2010). Journal of Trace Elements in Medicine and Biology 24 (2010) 58-66) Immunocytochemistry Analysis: A 1:100 dilution of this antibody from a representative lot detected DMT1 in Hela, A431, and N1H-3T3 cells
Other Notes: Concentration: Please refer to lot specific datasheet.