DEXD/H box helicase 60 (DDX60) is an interferon-inducible cytoplasmic helicase. DDX60,also called FLJ20035 is identified as an IFN-inducible gene in human dendritic cells following viral infection. DDX60 is located on human chromosome 4q32.3.
Synonyms: Anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60; Anti-FLJ20035
Storage: -20C
Application: Anti DDX60 antibodies may be used to detect DDX60 in HepG2-NTCP cells stimulated with IFN-? using western blotting.
Biochem Physiol Actions: DEXD/H box helicase 60 (DDX60) helps in RIG-I activation as well as viral RNA degradation. Both mechanisms are necessary for antiviral innate immune responses. DDX60 is used as a novel biomarker for tumorigenesis and diagnosis of oral squamous cell carcinoma (OSCC) specific to subsites such as buccal mucosal, lip and tongue.
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