DDRGK1 (DDRGK domain containing 1) gene is mapped to human chromosome 20p13 and the encoded protein contains a conserved PCI domain (Proteasome, COP9, and initiation factor-3) at the C-terminus that is also called as protein-protein interaction motif. The protein is localized to the endoplasmic reticulum.
Synonyms: Anti-DDRGK domain-containing protein 1 Precursor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: DDRGK1 (DDRGK domain containing 1) gene encodes a member of the DDRGK domain-containing protein family. The expression of this protein is induced by ER stress. It is found to interact with a protein complex containing UFL1 (UFM1-specific ligase 1), the putative tumor suppressor LZAP/C53 and UFM1 (ubiquitin fold modifier 1). UFL1 and LZAP/C53 are involved in the regulation of NF-?B pathway. DDRGK1 interacts with and stabilizes I?Ba (inhibitor of NF-?B) and in turn functions in the regulation of transcriptional activity of NF-?B and the expression of its target genes. Loss of DDRGK1 activity is found to inhibit cell proliferation.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC