DCBLD2 (discoidin, CUB and LCCL domain containing 2) is a novel neuropilin-like type-I transmembrane protein belonging to the neuropilin family. It is expressed in endothelial cells specifically in vascular smooth muscle cells. It is composed of a CUB domain and a coagulation factor V/VIII homology domain.
Synonyms: Anti-CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; Anti-Discoidin, CUB and LCCL domain-containing protein 2; Anti-Endothelial and smooth muscle cell-derived neuropilin-like protein
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem Physiol Actions: DCBLD2 (discoidin, CUB and LCCL domain containing 2) is highly involved in the regulation of vascular cell growth. It possesses tumor suppressive property, where it can suppress the cell migration signaling, and invasion of cancer cells. It acts as a potential gene for the miR-451a-mediated regulation in hypopharyngeal squamous cell carcinoma (HSCC). DCBLD2 regulates PDGFRß (Platelet-derived growth factor receptor ß) signaling by modulating receptor ubiquitination in vascular smooth muscle cells.
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