DAZL (Deleted in azoospermia-like) is a SPGYLA encoded RNA binding protein belonging to the DAZ (deleted in azoospermia) gene family. In humans, it is expressed in germ cells and male gonad.
Synonyms: Anti-DAZ homolog; Anti-DAZ-like autosomal; Anti-Deleted in azoospermia-like; Anti-Deleted in azoospermia-like 1; Anti-SPGY-like-autosomal
Storage: -20C
Application: Anti-DAZL antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: DAZL (Deleted in azoospermia-like) plays an important role in gametogenesis of both males and females. It is crucially important for spermatogenesis. It regulates translation by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets. Mutations in this gene may cause male infertility.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC