C-X3-C motif chemokine ligand 1(CX3CL1), also known as fractalkine (FKN), is encoded by the gene mapped to human chromosome 16q21. The encoded protein acts as a chemotactic cytokine in a soluble form, or acts as a binding molecule in a membrane-attached form. CX3CL1 is characterized by a mucin-like stalk containing chemokine domain and single transmembrane domain with a short intracellular C-terminal. CX3CL1 belongs to the CX3C chemokine subfamily.
Synonyms: Anti-Abcd-3; Anti-C3xkine; Anti-Chemokine (c-x3-c motif) ligand 1; Anti-Cxc3; Anti-Cxc3c; Anti-Fractalkine; Anti-Neurotactin; Anti-Ntn; Anti-Scyd1
MDL Number: MFCD01864668
Storage: -20C
Application: Anti-CX3CL1 antibody produced in rabbit has been used in tissue microarray (TMA) immunostaining.
Biochem Physiol Actions: CX3CL1 interacts with its cognate receptor CX3CR1 and stimulates chemotaxis of macrophages to apoptotic lymphocytes. The protein also facilitates inflammatory processes in the central nervous system (CNS). CX3CL1 has been implicated in the molecular mechanism that controls cell adhesion, migration and survival of human prostate cancer cells. Hence, the protein has potential therapeutic approach to treatment of prostate cancer. Elevated expression of serum CX3CL1 has been observed in postmenopausal osteoporotic patients. Thus, it acts as a potential diagnostic marker and therapeutic target for anti-resorptive treatment in osteoporosis patients.
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