Synonyms: Anti-Cathepsin H precursor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Cathepsin H is a protein encoded by the CTSH gene in humans. It is a unique member of the cysteine cathepsins that acts primarily as an aminopeptidase. The protein is synthesized as an inactive precursor and activated by proteolytic removal of its propeptide. It may be involved in graft versus host disease (GVHD) and anti-leukaemic/tumour responses. The gene encodes minor histocompatibility antigens (mHags) that could be targeted for graft versus leukaemia (GVL) effects. Cathepsin H is a lysosomal cysteine protease that may participate in tumor progression and may possess some roles during the progression of malignant disease.
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