CTNNB1 (ß catenin) is the core of Wnt signalling pathway that is highly conserved from nematodes to humans. ß-catenin signalling maintains the pluripotency of embryonic stem cells, generate embryonic cell diversity and determine lineage specification in normal tissue. One of the major proteins regulated by ß-catenin is glycogen synthase kinase 3 (GSK3) repotedly phosphorylates many targets of various other pathways. Dysregulation of Wnt signalling has been reported in cancers of liver, pancreas and gastrointestinal tract.
Synonyms: Anti-CTNNB; Anti-armadillo; Anti-beta-catenin
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
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