The gene CTBP1 (C-terminal-binding protein 1) is mapped to human chromosome 4p16.3. The protein localizes in the cytoplasm and the nucleus.
Synonyms: Anti-C-terminal-binding protein 1; Anti-CtBP1
MDL Number: MFCD04118431
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CTBP1 (C-terminal-binding protein 1) is a NADH (nicotinamide adenine dinucleotide hydrogen)-dependent transcriptional repressor. It binds with adenovirus type 2 and 5 E1A (early region 1A) protein. This interaction inhibits transcriptional activation and tumorigenesis associated with the E1A protein. It is a co-repressor of BCL6 (B-cell lymphoma 6 protein). Over-expression of CTBP1 disturbs epidermal and hair follicle homeostasis. It is up-regulated in hepatocellular carcinoma and is associated with epithelial-mesenchymal transition.
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