Synonyms: Anti-CREB-regulated transcription coactivator 1; Anti-Mucoepidermoid carcinoma translocated protein 1; Anti-TORC-1; Anti-Transducer of CREB protein 1; Anti-Transducer of regulated cAMP response element-binding protein 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CRTC1 (CREB regulated transcription coactivator 1) is a potent coactivator of CREB-dependent transcription. It has been reported to be found in the HBV (hepatitis B virus)-infected hepatoma cells and liver tissues. It controls CREB-dependent transcription in both rhythmic and light-evoked regulation. In animals, it maintains the energy requirement and balances body weight.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC