The gene CROCC (ciliary rootlet coiled-coil protein) is mapped to human chromosome 1p36.13. CROCC is commonly referred to as rootletin.
Synonyms: Anti-Ciliary rootlet coiled-coil protein; Anti-Rootletin
Storage: -20C
Application: Anti-CROCC antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CROCC (ciliary rootlet coiled-coil protein) is important for maintaining centrosome cohesion. It is responsible for forming centriole-associated fibers. CROCC also functions as a ciliary rootlet structural component. Down-regulation of CROCC in mice results in photoreceptor degeneration and negatively affects mucociliary clearance.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC